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KMID : 0603519980030010074
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Journal of Korean Association of Cancer Prevention
1998 Volume.3 No. 1 p.74 ~ p.82
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In vitro Antimutagenic and Anticarcinogenic Effect of Linoleic Acid Identified from Doenjang
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Lee Jeong-Min
Moon Suk-Hee
Park Kun-Young
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Abstract
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Antimutagenic and anticarcinogenic effects of linoleic acid were studied by using spore rec assay and SOS chromotest, and C3H/10T1/2 cells, respectively. Strong antimutagenic activities toward N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) and 4-nitroquino-line-1-oxide (4-NQO) were observed when linoleic acid, one of active compounds identified from traditional doenjang, was added in the test systems. In spore rec assay using Bacillus subtills Hl7 (rec+) and M45 (rec-), linoleic acid considerably inhibited the mutagenesis induced by MNNG. In SOS chromotest using Escherichia coli PQ37, linoleic acid also exhibited strong antimutagenic activity toward 4-NQO. Linoleic acid decreased the cytotoxicity induced by carcinogen, MNNG in C3H/10T1/2 cells. Type Ⅲ foci formation rate from the aflatoxin Bl (AFBl) treatment also decreased when linoleic acid was added to the C3H/10T1/2 cells, suggesting that linoleic acid might prevent the carcinogenesis mediated by AFBl.
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KEYWORD
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Linoleic acid, Antimutagenicity, Anticarcinogenicity, C3H/10T1/2 cells
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